The anti-tubercular activity of simvastatin is mediated by cholesterol-driven autophagy via the AMPK-mTORC1-TFEB axis

The anti-tubercular activity of simvastatin is mediated by cholesterol-driven autophagy via the AMPK-mTORC1-TFEB axis

The rise of drug-resistant tuberculosis poses a major risk to public health. Statins, which inhibit both cholesterol biosynthesis and protein prenylation branches of the mevalonate pathway, increase anti-tubercular antibiotic efficacy in animal models. However, the underlying molecular mechanisms ar...

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Bibliographic Details
Main Authors: Natalie Bruiners, Noton K. Dutta, Valentina Guerrini, Hugh Salamon, Ken D. Yamaguchi, Petros C. Karakousis, Maria L. Gennaro
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Journal of Lipid Research
Subjects:
Mycobacterium tuberculosis
statins
macrophages/monocytes
lipids
mechanistic target of rapamycin complex 1 regulation
immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520600232

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http://www.sciencedirect.com/science/article/pii/S0022227520600232

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