Physiological relevance of post-translational regulation of the spindle assembly checkpoint protein BubR1

Physiological relevance of post-translational regulation of the spindle assembly checkpoint protein BubR1

Abstract BubR1 is an essential component of the spindle assembly checkpoint (SAC) during mitosis where it functions to prevent anaphase onset to ensure proper chromosome alignment and kinetochore-microtubule attachment. Loss or mutation of BubR1 results in aneuploidy that precedes various potential...

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Bibliographic Details
Main Authors: Celia R. Bloom, Brian J. North
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Cell & Bioscience
Subjects:
Post-translational modifications
BubR1
Mitosis
Acetylation
Phosphorylation
Ubiquitination
Online Access:https://doi.org/10.1186/s13578-021-00589-2

Internet

https://doi.org/10.1186/s13578-021-00589-2

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