Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation

Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation

Mycobacterium bovis, the causative agent of tuberculosis in cattle and humans, infects host macrophages and induces endoplasmic reticulum stress (ERS), mitochondrial damage, and interleukin (IL)-1β production. The relationship between these phenotypes is yet to be elucidated. In this study, we inves...

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Bibliographic Details
Main Authors: Yi Liao, Tariq Hussain, Chunfa Liu, Yongyong Cui, Jie Wang, Jiao Yao, Hehua Chen, Yinjuan Song, Naveed Sabir, Mazhar Hussain, Deming Zhao, Xiangmei Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
Mycobacterium bovis
ERS
mitochondrial damage
inflammasome
IL-1β
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00268/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00268/full

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