Protein sites with more coevolutionary connections tend to evolve slower, while more variable protein families acquire higher coevolutionary connections [version 2; referees: 2 approved]

Background: Amino acid exchanges within proteins sometimes compensate for one another and could therefore be co-evolved. It is essential to investigate the intricate relationship between the extent of coevolution and the evolutionary variability exerted at individual protein sites, as well as the wh...

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Bibliographic Details
Main Authors: Sapan Mandloi, Saikat Chakrabarti
Format: Article
Language:English
Published: F1000 Research Ltd 2017-07-01
Series:F1000Research
Subjects:
Online Access:https://f1000research.com/articles/6-453/v2