NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development.

NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development.

A role for the NADPH oxidases NOX1 and NOX2 in liver fibrosis has been proposed, but the implication of NOX4 is poorly understood yet. The aim of this work was to study the functional role of NOX4 in different cell populations implicated in liver fibrosis: hepatic stellate cells (HSC), myofibroblats...

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Bibliographic Details
Main Authors: Patricia Sancho, Jèssica Mainez, Eva Crosas-Molist, César Roncero, Conrado M Fernández-Rodriguez, Fernando Pinedo, Heidemarie Huber, Robert Eferl, Wolfgang Mikulits, Isabel Fabregat
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23049784/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23049784/?tool=EBI

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