Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents
Xanthone scaffold has been regarded as an attractive chemical tool in the search for bioactive molecules with antitumor activity, and in particular two xanthone derivatives, 12-hydroxy-2,2-dimethyl-3,4-dihydro-2<i>H</i>,6<i>H</i>-pyrano [3,2-<i>b</i>]xanthen-6-one...
Main Authors: | Agostinho Lemos, Ana Sara Gomes, Joana B. Loureiro, Pedro Brandão, Andreia Palmeira, Madalena M. M. Pinto, Lucília Saraiva, Maria Emília Sousa |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-05-01
|
Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/24/10/1975 |
Similar Items
-
Strategies to Discover p53 Activators and a p73 Activator for Neuroblastoma
by: Emília Sousa, et al.
Published: (2019-08-01) -
Chalcones as Promising Antitumor Agents by Targeting the p53 Pathway: An Overview and New Insights in Drug-Likeness
by: Joana Moreira, et al.
Published: (2021-06-01) -
Antitumor Activity of Some Prenylated Xanthones
by: Raquel A.P. Castanheiro, et al.
Published: (2009-08-01) -
Chiral Derivatives of Xanthones with Antimicrobial Activity
by: Joana Araújo, et al.
Published: (2019-01-01) -
A pair of new enantiomers of xanthones from the stems and leaves of Cratoxylum cochinchinense
by: Cuicui Jia, et al.
Published: (2019-03-01)