Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents

Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents

Xanthone scaffold has been regarded as an attractive chemical tool in the search for bioactive molecules with antitumor activity, and in particular two xanthone derivatives, 12-hydroxy-2,2-dimethyl-3,4-dihydro-2<i>H</i>,6<i>H</i>-pyrano [3,2-<i>b</i>]xanthen-6-one...

Full description

Bibliographic Details
Main Authors: Agostinho Lemos, Ana Sara Gomes, Joana B. Loureiro, Pedro Brandão, Andreia Palmeira, Madalena M. M. Pinto, Lucília Saraiva, Maria Emília Sousa
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
antitumor activity
computational docking
MDM2-p53 interaction
xanthones
yeast-based assays
Online Access:https://www.mdpi.com/1420-3049/24/10/1975

Internet

https://www.mdpi.com/1420-3049/24/10/1975

Similar Items