Caspase-8: A Novel Target to Overcome Resistance to Chemotherapy in Glioblastoma

Caspase-8: A Novel Target to Overcome Resistance to Chemotherapy in Glioblastoma

Caspase-8 was originally identified as a central player of programmed cell death triggered by death receptor stimulation. In that context, its activity is tightly regulated through several mechanisms, with the best established being the expression of FLICE-like inhibitory protein (FLIP) family prote...

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Bibliographic Details
Main Authors: Giulia Fianco, Claudia Contadini, Alessandra Ferri, Claudia Cirotti, Venturina Stagni, Daniela Barilà
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
Caspase-8
glioblastoma
FLIP
Src kinase
tyrosine phosphorylation
NF-κB
tumor microenvironment
chemotherapy and radiotherapy
DNA damage
apoptosis
Online Access:https://www.mdpi.com/1422-0067/19/12/3798

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https://www.mdpi.com/1422-0067/19/12/3798

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