Cholesterol-Lowering Gene Therapy Prevents Heart Failure with Preserved Ejection Fraction in Obese Type 2 Diabetic Mice

Cholesterol-Lowering Gene Therapy Prevents Heart Failure with Preserved Ejection Fraction in Obese Type 2 Diabetic Mice

Hypercholesterolemia may be causally related to heart failure with preserved ejection fraction (HFpEF). We aimed to establish a HFpEF model associated with hypercholesterolemia and type 2 diabetes mellitus by feeding a high-sucrose/high-fat (HSHF) diet to C57BL/6J low-density lipoprotein receptor (L...

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Bibliographic Details
Main Authors: Joseph Pierre Aboumsallem, Ilayaraja Muthuramu, Mudit Mishra, Bart De Geest
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
gene therapy
heart failure with preserved ejection fraction
type 2 diabetes
oxidative stress
hypercholesterolemia
Online Access:https://www.mdpi.com/1422-0067/20/9/2222

Internet

https://www.mdpi.com/1422-0067/20/9/2222

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