Orai channel C-terminal peptides are key modulators of STIM-Orai coupling and calcium signal generation

Orai channel C-terminal peptides are key modulators of STIM-Orai coupling and calcium signal generation

Summary: Junctional coupling between endoplasmic reticulum (ER) Ca2+-sensor STIM proteins and plasma membrane (PM) Orai channels mediates Ca2+ signals in most cells. We reveal that PM-tethered, fluorescently tagged C-terminal M4x (fourth transmembrane helix contains a cytoplasmic C-terminal extensio...

Full description

Bibliographic Details
Main Authors: James H. Baraniak, Jr., Yandong Zhou, Robert M. Nwokonko, Michelle R. Jennette, Sarah A. Kazzaz, Jazmin M. Stenson, Abigale L. Whitsell, Youjun Wang, Mohamed Trebak, Donald L. Gill
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721006987

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721006987

Similar Items