Mortalin/glucose-regulated protein 75 promotes the cisplatin-resistance of gastric cancer via regulating anti-oxidation/apoptosis and metabolic reprogramming

Abstract Platinum drug treatment is one of the most predominant chemotherapeutic strategies for patients with gastric cancer (GC). However, the therapeutic effect is less than satisfactory, largely due to the acquired resistance to platinum drugs. Therefore, a better understanding of the underlying...

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Bibliographic Details
Main Authors: Yi Dai, Fan Li, Yuwen Jiao, Guoguang Wang, Tian Zhan, Yunwei Xia, Hanyang Liu, Haojun Yang, Jianping Zhang, Liming Tang
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00517-w