Correlation between β-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma

<p>Abstract</p> <p>Aberrant Wnt-signaling caused by mutants of β-catenin, a key regulator of the canonical Wnt-signaling pathway, is frequently detected in cancer. Only recently, it was suggested that in hepatocellular carcinoma (HCC) the expression of the target gene glutamine syn...

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Bibliographic Details
Main Authors: Gebhardt Rolf, Tannapfel Andrea, Wittekind Christian, Dunsch Ruediger, Austinat Madeleine, Gaunitz Frank
Format: Article
Language:English
Published: BMC 2008-02-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/7/1/21