Routine Cerebrospinal Fluid Cytology Reveals Unique Inclusions in Macrophages During Treatment With Nusinersen

Routine Cerebrospinal Fluid Cytology Reveals Unique Inclusions in Macrophages During Treatment With Nusinersen

Background: Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disorder characterized by degeneration of spinal motor neurons leading to muscular weakness. The antisense oligonucleotide nusinersen was approved for the treatment of patients with 5q-associated SMA. Treatment mus...

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Bibliographic Details
Main Authors: Stefan Gingele, Martin W. Hümmert, Sascha Alvermann, Konstantin F. Jendretzky, Lena Bönig, Marina Brieskorn, Philipp Schwenkenbecher, Kurt-Wolfram Sühs, Lars H. Müschen, Alma Osmanovic, Olivia Schreiber-Katz, Martin Stangel, Susanne Petri, Thomas Skripuletz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Neurology
Subjects:
nusinersen
spinal muscular atrophy (SMA)
cerebrospinal fluid (CSF)
cytology
macrophage
monocyte
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00735/full

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https://www.frontiersin.org/article/10.3389/fneur.2019.00735/full

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