Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models

Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models

Abstract The deposition of neurotoxic amyloid-β (Aβ) peptides in extracellular plaques in the brain parenchyma is one of the most prominent neuropathological features of Alzheimer’s disease (AD), and considered to be closely related to the pathogenesis of this disease. A number of recent studies dem...

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Bibliographic Details
Main Authors: Sathish Kumar, Cynthia A. Lemere, Jochen Walter
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Amyloid β peptide
Cerebral amyloid angiopathy
Down syndrome
Modified Aβ
Mouse models
Online Access:http://link.springer.com/article/10.1186/s40478-020-00959-w

Internet

http://link.springer.com/article/10.1186/s40478-020-00959-w

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