Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid

Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid

Unesterified cholesterol accumulation in the late endosomal/lysosomal (LE/LY) compartment is the cellular hallmark of Niemann-Pick C (NPC) disease, caused by defects in the genes encoding NPC1 or NPC2. We previously reported the dramatic stimulation of NPC2 cholesterol transport rates to and from mo...

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Bibliographic Details
Main Authors: Leslie A McCauliff, Annette Langan, Ran Li, Olga Ilnytska, Debosreeta Bose, Miriam Waghalter, Kimberly Lai, Peter C Kahn, Judith Storch
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
Niemann Pick C
lysosomal storage disease
cholesterol
NPC2
lipid-protein interaction
lysobisphosphatidic acid
Online Access:https://elifesciences.org/articles/50832

Internet

https://elifesciences.org/articles/50832

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