Oncolytic Reovirus and Immune Checkpoint Inhibition as a Novel Immunotherapeutic Strategy for Breast Cancer

Oncolytic Reovirus and Immune Checkpoint Inhibition as a Novel Immunotherapeutic Strategy for Breast Cancer

As the current efficacy of oncolytic viruses (OVs) as monotherapy is limited, exploration of OVs as part of a broader immunotherapeutic treatment strategy for cancer is necessary. Here, we investigated the ability for immune checkpoint blockade to enhance the efficacy of oncolytic reovirus (RV) for...

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Bibliographic Details
Main Authors: Ahmed A. Mostafa, Daniel E. Meyers, Chandini M. Thirukkumaran, Peter J. Liu, Kathy Gratton, Jason Spurrell, Qiao Shi, Satbir Thakur, Don G. Morris
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Cancers
Subjects:
oncolytic viruses
reovirus
immune checkpoint inhibition
PD-1
breast cancer
immunotherapy
Online Access:http://www.mdpi.com/2072-6694/10/6/205

Internet

http://www.mdpi.com/2072-6694/10/6/205

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