Pathophysiology and potential future therapeutic targets using preclinical models of COVID-19

Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) gains entry into the lung epithelial cells by binding to the surface protein angiotensin-converting enzyme 2. Severe SARS-CoV-2 infection, also known as coronavirus disease 2019 (COVID-19), can lead to death due to acute respiratory distre...

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Bibliographic Details
Main Authors: Rahul Kumar, Michael H. Lee, Claudia Mickael, Biruk Kassa, Qadar Pasha, Rubin Tuder, Brian Graham
Format: Article
Language:English
Published: European Respiratory Society 2020-12-01
Series:ERJ Open Research
Online Access:http://openres.ersjournals.com/content/6/4/00405-2020.full