Metformin Inhibits Lipoteichoic Acid–Induced Oxidative Stress and Inflammation Through AMPK/NRF2/NF-κB Signaling Pathway in Bovine Mammary Epithelial Cells

Metformin Inhibits Lipoteichoic Acid–Induced Oxidative Stress and Inflammation Through AMPK/NRF2/NF-κB Signaling Pathway in Bovine Mammary Epithelial Cells

The objective of this research was to explore the effect of metformin on the lipoteichoic acid (LTA)–induced mastitis model using isolated primary bovine mammary epithelial cells (PBMECs). The PBMECs were exposed to either 3 mM metformin for 12 h as a metformin group (MET) or 100 μg/mL LTA for 6 h a...

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Bibliographic Details
Main Authors: Abdelaziz Adam Idriss Arbab, Xubin Lu, Ismail Mohamed Abdalla, Amer Adam Idris, Zhi Chen, Mingxun Li, Yongjiang Mao, Tianle Xu, Zhangping Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Veterinary Science
Subjects:
metformin
AMPK signaling
antioxidant
anti-inflammation
bovine mammary epithelium cells
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2021.661380/full

Internet

https://www.frontiersin.org/articles/10.3389/fvets.2021.661380/full

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