Synovial tissue macrophages: friend or foe?

Healthy synovial tissue includes a lining layer of synovial fibroblasts and macrophages. The influx of leucocytes during active rheumatoid arthritis (RA) includes monocytes that differentiate locally into proinflammatory macrophages, and these produce pathogenic tumour necrosis factor. During sustai...

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Bibliographic Details
Main Authors: Stefano Alivernini, Mariola Kurowska-Stolarska
Format: Article
Language:English
Published: BMJ Publishing Group 2017-12-01
Series:RMD Open
Online Access:https://rmdopen.bmj.com/content/3/2/e000527.full