Impact of Different JAK Inhibitors and Methotrexate on Lymphocyte Proliferation and DNA Damage

Impact of Different JAK Inhibitors and Methotrexate on Lymphocyte Proliferation and DNA Damage

Janus kinase inhibitors (JAKis) represent a new strategy in rheumatoid arthritis (RA) therapy. Still, data directly comparing different JAKis are rare. In the present in vitro study, we investigated the immunomodulatory potential of four JAKis (tofacitinib, baricitinib, upadacitinib, and filgotinib)...

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Bibliographic Details
Main Authors: Annika Reddig, Linda Voss, Karina Guttek, Dirk Roggenbuck, Eugen Feist, Dirk Reinhold
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Journal of Clinical Medicine
Subjects:
JAK inhibitor
proliferation
DNA damage repair
γH2AX
PBMCs
T lymphocytes
Online Access:https://www.mdpi.com/2077-0383/10/7/1431

Internet

https://www.mdpi.com/2077-0383/10/7/1431

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