RNAi-mediated depletion of the NSL complex subunits leads to abnormal chromosome segregation and defective centrosome duplication in Drosophila mitosis.

RNAi-mediated depletion of the NSL complex subunits leads to abnormal chromosome segregation and defective centrosome duplication in Drosophila mitosis.

The Drosophila Nonspecific Lethal (NSL) complex is a major transcriptional regulator of housekeeping genes. It contains at least seven subunits that are conserved in the human KANSL complex: Nsl1/Wah (KANSL1), Dgt1/Nsl2 (KANSL2), Rcd1/Nsl3 (KANSL3), Rcd5 (MCRS1), MBD-R2 (PHF20), Wds (WDR5) and Mof (...

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Bibliographic Details
Main Authors: Gera A Pavlova, Julia V Popova, Evgeniya N Andreyeva, Lyubov A Yarinich, Mikhail O Lebedev, Alyona V Razuvaeva, Tatiana D Dubatolova, Anastasiya L Oshchepkova, Claudia Pellacani, Maria Patrizia Somma, Alexey V Pindyurin, Maurizio Gatti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-09-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008371

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https://doi.org/10.1371/journal.pgen.1008371

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