Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage

Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage

The persistence of leukemia stem cells (LSCs) is one of the leading causes of chemoresistance in acute myeloid leukemia (AML). To explore the factors important in LSC-mediated resistance, we use mass spectrometry to screen the factors related to LSC chemoresistance and defined IFN-γ-inducible lysoso...

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Bibliographic Details
Main Authors: Li-Ting Niu, Yu-Qing Wang, Catherine C.L. Wong, Shuai-Xin Gao, Xiao-Dong Mo, Xiao-Jun Huang
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Translational Oncology
Subjects:
AML
Chemoresistance
LSC
GILT
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321001510

Internet

http://www.sciencedirect.com/science/article/pii/S1936523321001510

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