Effect of Neonatal Treatment With the NMDA Receptor Antagonist, MK-801, During Different Temporal Windows of Postnatal Period in Adult Prefrontal Cortical and Hippocampal Function

Effect of Neonatal Treatment With the NMDA Receptor Antagonist, MK-801, During Different Temporal Windows of Postnatal Period in Adult Prefrontal Cortical and Hippocampal Function

The neonatal MK-801 model of schizophrenia has been developed based on the neurodevelopmental and NMDA receptor hypofunction hypotheses of schizophrenia. This animal model is generated with the use of the NMDA receptor antagonist, MK-801, during different temporal windows of postnatal life of rodent...

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Bibliographic Details
Main Authors: Maria E. Plataki, Konstantinos Diskos, Christos Sougklakos, Marouso Velissariou, Alexandros Georgilis, Vasiliki Stavroulaki, Kyriaki Sidiropoulou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
object recognition
social behavior
contextual fear conditioning
up states
neuronal oscillations
parvalbumin interneurons
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2021.689193/full

Internet

https://www.frontiersin.org/articles/10.3389/fnbeh.2021.689193/full

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