Novel Kazal-type proteinase inhibitors from the skin secretion of the Splendid leaf frog, Cruziohyla calcarifer

Novel Kazal-type proteinase inhibitors from the skin secretion of the Splendid leaf frog, Cruziohyla calcarifer

Peptidase inhibitors have an important role controlling a variety of biological processes. Here, we employed a peptidomic approach including molecular cloning, tandem mass spectrometry and enzymatic assays to reveal 7 Kazal-type proteinase inhibitors (CCKPs) (18 variants) in the skin secretion of th...

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Bibliographic Details
Main Authors: Carolina Proaño-Bolaños, Renjie Li, Mei Zhou, Lei Wang, Xinping Xi, Elicio E. Tapia, Luis A. Coloma, Tianbao Chen, Chris Shaw
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:EuPA Open Proteomics
Subjects:
Kazal-type proteinase inhibitors
Frog skin secretion
Peptidomic
Molecular cloning
Tandem mass spectrometry
Cruziohyla calcarifer
Online Access:http://www.sciencedirect.com/science/article/pii/S221296851630037X

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http://www.sciencedirect.com/science/article/pii/S221296851630037X

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