Diastereoselective synthesis of chiral 1,3-cyclohexadienals.

A novel approach to the production of chiral 1,3-cyclohexadienals has been developed. The organocatalysed asymmetric reaction of different β-disubstituted-α,β-unsaturated aldehydes with a chiral α,β-unsaturated aldehyde in the presence of a Jørgensen-Hayashi organocatalyst provides easy and stereoco...

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Bibliographic Details
Main Authors: Aitor Urosa, Ignacio E Tobal, Ángela P de la Granja, M Carmen Capitán, R F Moro, Isidro S Marcos, Narciso M Garrido, Francisca Sanz, Emilio Calle, David Díez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5810990?pdf=render