MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation

MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation

Mutations in MECP2, encoding methyl CpG binding protein 2, cause the neurodevelopmental disorder Rett syndrome. MeCP2 is an abundant nuclear protein that binds to chromatin and modulates transcription in response to neuronal activity. Prior studies of MeCP2 function have focused on specific gene tar...

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Bibliographic Details
Main Authors: Malaika K. Singleton, Michael L. Gonzales, Karen N. Leung, Dag H. Yasui, Diane I. Schroeder, Keith Dunaway, Janine M. LaSalle
Format: Article
Language:English
Published: Elsevier 2011-07-01
Series:Neurobiology of Disease
Subjects:
MeCP2
DNA methylation
Maturation
Chromatin
Nucleoli
Neuronal
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111000933

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http://www.sciencedirect.com/science/article/pii/S0969996111000933

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