A comparison of AAV-vector production methods for gene therapy and preclinical assessment

A comparison of AAV-vector production methods for gene therapy and preclinical assessment

Abstract Adeno Associated Virus (AAV)-mediated gene expression in the brain is widely applied in the preclinical setting to investigate the therapeutic potential of specific molecular targets, characterize various cellular functions, and model central nervous system (CNS) diseases. In therapeutic ap...

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Bibliographic Details
Main Authors: Marcus Davidsson, Matilde Negrini, Swantje Hauser, Alexander Svanbergsson, Marcus Lockowandt, Giuseppe Tomasello, Fredric P. Manfredsson, Andreas Heuer
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-78521-w

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https://doi.org/10.1038/s41598-020-78521-w

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