Common genes associated with antidepressant response in mouse and man identify key role of glucocorticoid receptor sensitivity.

Common genes associated with antidepressant response in mouse and man identify key role of glucocorticoid receptor sensitivity.

Response to antidepressant treatment in major depressive disorder (MDD) cannot be predicted currently, leading to uncertainty in medication selection, increasing costs, and prolonged suffering for many patients. Despite tremendous efforts in identifying response-associated genes in large genome-wide...

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Bibliographic Details
Main Authors: Tania Carrillo-Roa, Christiana Labermaier, Peter Weber, David P Herzog, Caleb Lareau, Sara Santarelli, Klaus V Wagner, Monika Rex-Haffner, Daniela Harbich, Sebastian H Scharf, Charles B Nemeroff, Boadie W Dunlop, W Edward Craighead, Helen S Mayberg, Mathias V Schmidt, Manfred Uhr, Florian Holsboer, Inge Sillaber, Elisabeth B Binder, Marianne B Müller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-12-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2002690

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https://doi.org/10.1371/journal.pbio.2002690

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