Treatment With Medicinal Mushroom Extract Mixture Inhibits Translation and Reprograms Metabolism in Advanced Colorectal Cancer Animal Model as Evidenced by Tandem Mass Tags Proteomics Analysis

Treatment With Medicinal Mushroom Extract Mixture Inhibits Translation and Reprograms Metabolism in Advanced Colorectal Cancer Animal Model as Evidenced by Tandem Mass Tags Proteomics Analysis

Colorectal cancer (CRC) is the third most frequent cancer type in both males and females, with about 35% of patients being diagnosed in stage IV metastatic disease. Despite advancements in treatment, life expectancy in patients with metastatic disease is still not satisfying. Due to frequent drug re...

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Bibliographic Details
Main Authors: Boris Jakopovic, Anita Horvatić, Marko Klobučar, Andrea Gelemanović, Petra Grbčić, Nada Oršolić, Ivan Jakopovich, Sandra Kraljević Pavelić
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
colorectal cancer
medicinal mushrooms
tandem mass tags proteomics
translation
cancer metabolism
unfolded protein response
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01202/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01202/full

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