Intrinsic Abnormalities of Cystic Fibrosis Airway Connective Tissue Revealed by an In Vitro 3D Stromal Model

Intrinsic Abnormalities of Cystic Fibrosis Airway Connective Tissue Revealed by an In Vitro 3D Stromal Model

Cystic fibrosis is characterized by lung dysfunction involving mucus hypersecretion, bacterial infections, and inflammatory response. Inflammation triggers pro-fibrotic signals that compromise lung structure and function. At present, several in vitro cystic fibrosis models have been developed to stu...

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Bibliographic Details
Main Authors: Claudia Mazio, Laura S. Scognamiglio, Rossella De Cegli, Luis J.V. Galietta, Diego Di Bernardo, Costantino Casale, Francesco Urciuolo, Giorgia Imparato, Paolo A. Netti
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cells
Subjects:
cystic fibrosis
connective airway tissue
lung fibroblasts
extracellular matrix
3D bioengineered model
RNA sequencing
Online Access:https://www.mdpi.com/2073-4409/9/6/1371

Internet

https://www.mdpi.com/2073-4409/9/6/1371

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