Adipocyte/breast cancer cell crosstalk in obesity interferes with the anti-proliferative efficacy of tamoxifen.

Adipocyte/breast cancer cell crosstalk in obesity interferes with the anti-proliferative efficacy of tamoxifen.

Obesity is a well-known risk factor of breast cancer in post-menopausal women that also correlates with a diminished therapeutic response. The influence of adipocytes and their secretome, i.e. adipokines, on the efficacy of hormone therapy has yet to be elucidated.We investigated, ex vivo, whether m...

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Bibliographic Details
Main Authors: Lauriane Bougaret, Laetitia Delort, Hermine Billard, Camille Le Huede, Céline Boby, Anne De la Foye, Adrien Rossary, Ali Mojallal, Odile Damour, Céline Auxenfans, Marie Paule Vasson, Florence Caldefie-Chezet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5794086?pdf=render

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http://europepmc.org/articles/PMC5794086?pdf=render

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