Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans

Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans

In Caenorhabditis elegans, mutations in WDR-5 and other components of the COMPASS H3K4 methyltransferase complex extend lifespan and enable its inheritance. Here, we show that wdr-5 mutant longevity is itself a transgenerational trait that corresponds with a global enrichment of the heterochromatin...

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Bibliographic Details
Main Authors: Teresa Wei-sy Lee, Heidi Shira David, Amanda Kathryn Engstrom, Brandon Scott Carpenter, David John Katz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
transgenerational inheritance
epigenetics
aging
heterochromatin
COMPASS
chromatin
Online Access:https://elifesciences.org/articles/48498

Internet

https://elifesciences.org/articles/48498

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