Synthesis and preliminary ex vivo evaluation of the spasmolytic activity of 1,3-thiazolium- and 1,3,4-thiadiazolium-5-methylthio- and 5-thioacetate derivatives

Synthesis and preliminary ex vivo evaluation of the spasmolytic activity of 1,3-thiazolium- and 1,3,4-thiadiazolium-5-methylthio- and 5-thioacetate derivatives

Seven new compounds have been synthetized in satisfactory yields (51-78 %) through the treatment of mesoionic 1,3-thiazolium-5-thiolate (4a-d) and 1,3,4-thiadiazolium- 5-thiolate (10a,b) with chloroacetic acid or methyl iodide: 1,3,4-thiadiazolium-5-methylthio- (11) and 5-thioacetate (12). The struc...

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Bibliographic Details
Main Authors: Luis José A. S., Aquino Thiago M. De, Lira Bruno F., Filho Petrônio F. A., Scotti Marcus T., Scotti Luciana, Moura Ricardo O. De, Junior Francisco J. B. Mendonça
Format: Article
Language:English
Published: Sciendo 2014-06-01
Series:Acta Pharmaceutica
Subjects:
1,3-thiazolium
1,3,4-thiadiazolium
mesoionic derivatives
spasmolytic activity
Online Access:http://www.degruyter.com/view/j/acph.2014.64.issue-2/acph-2014-0016/acph-2014-0016.xml?format=INT

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http://www.degruyter.com/view/j/acph.2014.64.issue-2/acph-2014-0016/acph-2014-0016.xml?format=INT

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