Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway

Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway

Unequal transmission of nutritive signaling during cell division establishes fate disparity between sibling lymphocytes, but how asymmetric signaling becomes organized is not understood. We show that receptor-associated class I phosphatidylinositol 3-kinase (PI3K) signaling activity, indexed by phos...

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Bibliographic Details
Main Authors: Yen-Hua Chen, Radomir Kratchmarov, Wen-Hsuan W. Lin, Nyanza J. Rothman, Bonnie Yen, William C. Adams, Simone A. Nish, Jeffrey C. Rathmell, Steven L. Reiner
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Subjects:
TCF1
FoxO1
Pax5
mTOR
stem cell
anabolism
Warburg effect
asymmetric division
actin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717319241

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http://www.sciencedirect.com/science/article/pii/S2211124717319241

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