Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis

Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis

Summary: Type 2 diabetes is characterized by peripheral insulin resistance and insufficient insulin release from pancreatic islet β cells. However, the role and sequence of β cell dysfunction and mass loss for reduced insulin levels in type 2 diabetes pathogenesis are unclear. Here, we exploit fresh...

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Bibliographic Details
Main Authors: Christian M. Cohrs, Julia K. Panzer, Denise M. Drotar, Stephen J. Enos, Nicole Kipke, Chunguang Chen, Robert Bozsak, Eyke Schöniger, Florian Ehehalt, Marius Distler, Ana Brennand, Stefan R. Bornstein, Jürgen Weitz, Michele Solimena, Stephan Speier
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720303478

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http://www.sciencedirect.com/science/article/pii/S2211124720303478

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