Silencing of HMGA2 by siRNA Loaded Methotrexate Functionalized Polyamidoamine Dendrimer for Human Breast Cancer Cell Therapy

Silencing of HMGA2 by siRNA Loaded Methotrexate Functionalized Polyamidoamine Dendrimer for Human Breast Cancer Cell Therapy

The transcription factor high mobility group protein A2 (HMGA2) plays an important role in the pathogenesis of some cancers including breast cancer. Polyamidoamine dendrimer generation 4 is a kind of highly branched polymeric nanoparticle with surface charge and highest density peripheral groups tha...

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Bibliographic Details
Main Authors: Fereydoon Abedi Gaballu, William Chi-Shing Cho, Gholamreza Dehghan, Amir Zarebkohan, Behzad Baradaran, Behzad Mansoori, Soheil Abbaspour-Ravasjani, Ali Mohammadi, Nader Sheibani, Ayuob Aghanejad, Jafar Ezzati Nazhad Dolatabadi
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Genes
Subjects:
apoptosis
dendrimer
HMGA2 <i>siRNA</i>
methotrexate
breast cancer
Online Access:https://www.mdpi.com/2073-4425/12/7/1102

Internet

https://www.mdpi.com/2073-4425/12/7/1102

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