Asymmetry in Erythroid-Myeloid differentiation switch and the role of timing in a binary cell fate decision

GATA1-PU.1 genetic switch is a paradigmatic genetic switch that governs the differentiation of progenitor cells into two different fates, erythroid and myeloid fates. In terms of dynamical model representation of these fates or lineages corresponds to stable attractor and choosing between the attra...

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Bibliographic Details
Main Authors: Afnan eAlagha, Alexey eZaikin
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00426/full