Corneal kindled C57BL/6 mice exhibit saturated dentate gyrus long-term potentiation and associated memory deficits in the absence of overt neuron loss

Corneal kindled C57BL/6 mice exhibit saturated dentate gyrus long-term potentiation and associated memory deficits in the absence of overt neuron loss

Memory deficits have a significant impact on the quality of life of patients with epilepsy and currently no effective treatments exist to mitigate this comorbidity. While these cognitive comorbidities can be associated with varying degrees of hippocampal cell death and hippocampal sclerosis, more su...

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Bibliographic Details
Main Authors: Gregory J. Remigio, Jaycie L. Loewen, Sage Heuston, Colin Helgeson, H. Steve White, Karen S. Wilcox, Peter J. West
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Neurobiology of Disease
Subjects:
Seizures
Corneal kindling
Hippocampus
Dentate gyrus
Hyperexcitability
Synaptic plasticity
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611730133X

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http://www.sciencedirect.com/science/article/pii/S096999611730133X

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