Pyrazolo[3,4-d]pyrimidine based scaffold derivatives targeting kinases as anticancer agents

Pyrazolo[3,4-d]pyrimidine based scaffold derivatives targeting kinases as anticancer agents

Pyrazolopyrimidines are fused heterocyclic ring systems which structurally can consider as bioisosteres of adenine, which is fundamental for every aspect of cell life. Pyrazolo[3,4-d]pyrimidines derivatives have been explored for their inhibitory activity towards various protein kinase enzymes and t...

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Bibliographic Details
Main Authors: Nasser S.M. Ismail, Eslam M.H. Ali, Diaa A. Ibrahim, Rabah A.T. Serya, Dalal A. Abou El Ella
Format: Article
Language:English
Published: SpringerOpen 2016-06-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Protein kinase
Bioisostere
Pyrazolo[3,4-d]pyrimidine
Synthetic strategy
SAR
Online Access:http://www.sciencedirect.com/science/article/pii/S2314724515300169

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http://www.sciencedirect.com/science/article/pii/S2314724515300169

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