Estimation of the fraction of cancer cells in a tumor DNA sample using DNA methylation.

Estimation of the fraction of cancer cells in a tumor DNA sample using DNA methylation.

Contamination of normal cells is almost always present in tumor samples and affects their molecular analyses. DNA methylation, a stable epigenetic modification, is cell type-dependent, and different between cancer and normal cells. Here, we aimed to demonstrate that DNA methylation can be used to es...

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Bibliographic Details
Main Authors: Takamasa Takahashi, Yasunori Matsuda, Satoshi Yamashita, Naoko Hattori, Ryoji Kushima, Yi-Chia Lee, Hiroyasu Igaki, Yuji Tachimori, Masato Nagino, Toshikazu Ushijima
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3846724?pdf=render

Internet

http://europepmc.org/articles/PMC3846724?pdf=render

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