Multiple selective sweeps of ancient polymorphisms in and around LTα located in the MHC class III region on chromosome 6

Multiple selective sweeps of ancient polymorphisms in and around LTα located in the MHC class III region on chromosome 6

Abstract Background Lymphotoxin-α (LTα), located in the Major Histocompatibility Complex (MHC) class III region on chromosome 6, encodes a cytotoxic protein that mediates a variety of antiviral responses among other biological functions. Furthermore, several genotypes at this gene have been implicat...

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Bibliographic Details
Main Authors: Michael C. Campbell, Bryan Ashong, Shaolei Teng, Jayla Harvey, Christopher N. Cross
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Evolutionary Biology
Subjects:
Archaic hominins
Human population genetics
MHC class III region
Balancing selection
Soft selective sweep
Online Access:https://doi.org/10.1186/s12862-019-1516-y

Internet

https://doi.org/10.1186/s12862-019-1516-y

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