Metabolic pathway and biological significance of glutathione detoxification of aristolochic acid Ⅰ
Aristolochic acid I (AAI) is a nephrotoxic chemical found in the plant genera, Aristolochia and Asarum. AAI can be reduced to positively charged aristolochyl actam-nitrogen ions in organisms: this intermediate product increases the oxidative stress due to AAI. Glutathione (GSH) acts synergistically...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-09-01
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| Series: | Journal of Photochemistry and Photobiology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666469021000397 |