Anti-Glucosylsphingosine Autoimmunity, JAK2V617F-Dependent Interleukin-1β and JAK2V617F-Independent Cytokines in Myeloproliferative Neoplasms

Anti-Glucosylsphingosine Autoimmunity, JAK2V617F-Dependent Interleukin-1β and JAK2V617F-Independent Cytokines in Myeloproliferative Neoplasms

Inflammatory cytokines play a major role in myeloproliferative neoplasms (MPNs) as regulators of the MPN clone and as mediators of clinical symptoms and complications. Firstly, we investigated the effect of <i>JAK2</i>V617F on 42 molecules linked to inflammation. For <i>JAK2</i&...

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Bibliographic Details
Main Authors: Sophie Allain-Maillet, Adrien Bosseboeuf, Nicolas Mennesson, Mégane Bostoën, Laura Dufeu, Eun Ho Choi, Cédric Cleyrat, Olivier Mansier, Eric Lippert, Yannick Le Bris, Jean-Marc Gombert, François Girodon, Magali Pettazzoni, Edith Bigot-Corbel, Sylvie Hermouet
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
myeloproliferative neoplasms (MPNs)
inflammation
cytokines
<i>JAK2</i>V617F
<i>CALR</i> exon 9 mutants
interleukin-1β (IL-1β)
Online Access:https://www.mdpi.com/2072-6694/12/9/2446

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https://www.mdpi.com/2072-6694/12/9/2446

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