Lymphopenia-induced proliferation in Aire-deficient mice helps to explain their autoimmunity and differences from human patients
Studies on autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) and its mouse model – both caused by mutant AIRE – have greatly advanced the under-standing of thymic processes that generate a self-tolerant T-cell repertoire. Much is now known about the molecular mechanisms by whic...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00051/full |