Overlaid positive and negative feedback loops shape dynamical properties of PhoPQ two-component system.

Bacteria use two-component systems (TCSs) to sense environmental conditions and change gene expression in response to those conditions. To amplify cellular responses, many bacterial TCSs are under positive feedback control, i.e. increase their expression when activated. Escherichia coli Mg2+ -sensin...

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Bibliographic Details
Main Authors: Satyajit D Rao, Oleg A Igoshin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1008130