GLI2 Modulated by SUFU and SPOP Induces Intestinal Stem Cell Niche Signals in Development and Tumorigenesis

GLI2 Modulated by SUFU and SPOP Induces Intestinal Stem Cell Niche Signals in Development and Tumorigenesis

Summary: Gut mesenchyme provides key stem cell niche signals such as Wnt ligands, but how these signals are regulated is unclear. Because Hedgehog (Hh) signaling is critical for gut mesenchymal development and tumorigenesis, we investigated Hh-mediated mechanisms by analyzing mice deleted for key ne...

Full description

Bibliographic Details
Main Authors: Sabrina Coquenlorge, Wen-Chi Yin, Theodora Yung, Jingyi Pan, Xiaoyun Zhang, Rong Mo, Jaques Belik, Chi-chung Hui, Tae-Hee Kim
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719306278

Internet

http://www.sciencedirect.com/science/article/pii/S2211124719306278

Similar Items