Uncoordinated transcription and compromised muscle function in the lmna-null mouse model of Emery- Emery-Dreyfuss muscular dystrophy.

Uncoordinated transcription and compromised muscle function in the lmna-null mouse model of Emery- Emery-Dreyfuss muscular dystrophy.

LMNA encodes both lamin A and C: major components of the nuclear lamina. Mutations in LMNA underlie a range of tissue-specific degenerative diseases, including those that affect skeletal muscle, such as autosomal-Emery-Dreifuss muscular dystrophy (A-EDMD) and limb girdle muscular dystrophy 1B. Here,...

Full description

Bibliographic Details
Main Authors: Viola F Gnocchi, Juergen Scharner, Zhe Huang, Ken Brady, Jaclyn S Lee, Robert B White, Jennifer E Morgan, Yin-Biao Sun, Juliet A Ellis, Peter S Zammit
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3043058?pdf=render

Internet

http://europepmc.org/articles/PMC3043058?pdf=render

Similar Items