Enhanced responses to angiogenic cues underlie the pathogenesis of hereditary hemorrhagic telangiectasia 2.

Enhanced responses to angiogenic cues underlie the pathogenesis of hereditary hemorrhagic telangiectasia 2.

Hereditary Hemorrhagic Telangiectasia (HHT) is a genetic vascular disease in which arteriovenous malformations (AVMs) manifest in skin and multiple visceral organs. HHT is caused by heterozygous mutations in endoglin (ENG), activin receptor-like kinase 1 (ALK1), or SMAD4. ALK1 regulates angiogenesis...

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Bibliographic Details
Main Authors: Eun-Jung Choi, Yong Hwan Kim, Se-woon Choe, Yu Gyoung Tak, Eva M Garrido-Martin, Myron Chang, Young Jae Lee, S Paul Oh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3651154?pdf=render

Internet

http://europepmc.org/articles/PMC3651154?pdf=render

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