Asymmetric Conservation within Pairs of Co-Occurred Motifs Mediates Weak Direct Binding of Transcription Factors in ChIP-Seq Data

Asymmetric Conservation within Pairs of Co-Occurred Motifs Mediates Weak Direct Binding of Transcription Factors in ChIP-Seq Data

(1) Background: Transcription factors (TFs) are main regulators of eukaryotic gene expression. The cooperative binding to genomic DNA of at least two TFs is the widespread mechanism of transcription regulation. Cooperating TFs can be revealed through the analysis of co-occurrence of their motifs. (2...

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Bibliographic Details
Main Authors: Victor Levitsky, Dmitry Oshchepkov, Elena Zemlyanskaya, Tatyana Merkulova
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
chromatin immunoprecipitation with massively parallel sequencing
transcription factors binding sites prediction
cooperative binding of transcription factors
composite elements
motifs conservation
classification of transcription factors
Online Access:https://www.mdpi.com/1422-0067/21/17/6023

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https://www.mdpi.com/1422-0067/21/17/6023

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