Asymmetric Conservation within Pairs of Co-Occurred Motifs Mediates Weak Direct Binding of Transcription Factors in ChIP-Seq Data

by Victor Levitsky, Dmitry Oshchepkov, Elena Zemlyanskaya, Tatyana Merkulova
Published 2020-08-01

Candidate SNP Markers of Atherogenesis Significantly Shifting the Affinity of TATA-Binding Protein for Human Gene Promoters Show Stabilizing Natural Selection as a Sum of Neutral D...

by Mikhail Ponomarenko, Dmitry Rasskazov, Irina Chadaeva, Ekaterina Sharypova, Irina Drachkova, Dmitry Oshchepkov, Petr Ponomarenko, Ludmila Savinkova, Evgeniya Oshchepkova, Maria Nazarenko, Nikolay Kolchanov
Published 2020-02-01

A Rat Model of Human Behavior Provides Evidence of Natural Selection Against Underexpression of Aggressiveness-Related Genes in Humans

by Dmitry Oshchepkov, Mikhail Ponomarenko, Mikhail Ponomarenko, Natalya Klimova, Irina Chadaeva, Irina Chadaeva, Anatoly Bragin, Ekaterina Sharypova, Ekaterina Sharypova, Svetlana Shikhevich, Rimma Kozhemyakina, Rimma Kozhemyakina
Published 2019-12-01

Domestication Explains Two-Thirds of Differential-Gene-Expression Variance between Domestic and Wild Animals; The Remaining One-Third Reflects Intraspecific and Interspecific Varia...

by Irina Chadaeva, Petr Ponomarenko, Rimma Kozhemyakina, Valentin Suslov, Anton Bogomolov, Natalya Klimova, Svetlana Shikhevich, Ludmila Savinkova, Dmitry Oshchepkov, Nikolay A. Kolchanov, Arcady Markel, Mikhail Ponomarenko
Published 2021-09-01

A Bioinformatics Model of Human Diseases on the Basis of Differentially Expressed Genes (of Domestic versus Wild Animals) That Are Orthologs of Human Genes Associated with Reproduc...

by Gennady Vasiliev, Irina Chadaeva, Dmitry Rasskazov, Petr Ponomarenko, Ekaterina Sharypova, Irina Drachkova, Anton Bogomolov, Ludmila Savinkova, Mikhail Ponomarenko, Nikolay Kolchanov, Alexander Osadchuk, Dmitry Oshchepkov, Ludmila Osadchuk
Published 2021-02-01

Disruptive Selection of Human Immunostimulatory and Immunosuppressive Genes Both Provokes and Prevents Rheumatoid Arthritis, Respectively, as a Self-Domestication Syndrome

by Natalya V. Klimova, Evgeniya Oshchepkova, Irina Chadaeva, Ekaterina Sharypova, Petr Ponomarenko, Irina Drachkova, Dmitry Rasskazov, Dmitry Oshchepkov, Mikhail Ponomarenko, Mikhail Ponomarenko, Ludmila Savinkova, Nikolay A. Kolchanov, Vladimir Kozlov
Published 2021-06-01

Disruptive natural selection by male reproductive potential prevents underexpression of protein-coding genes on the human Y chromosome as a self-domestication syndrome

by Mikhail Ponomarenko, Maxim Kleshchev, Petr Ponomarenko, Irina Chadaeva, Ekaterina Sharypova, Dmitry Rasskazov, Semyon Kolmykov, Irina Drachkova, Gennady Vasiliev, Natalia Gutorova, Elena Ignatieva, Ludmila Savinkova, Anton Bogomolov, Ludmila Osadchuk, Alexandr Osadchuk, Dmitry Oshchepkov
Published 2020-10-01